Virology - Influenza

Influenza and enzootic viruses

The core research area is influenza in birds and pigs. The research focuses on investigating the factors that determine whether a specific influenza can infect humans as well as the viral determinants, which control the virus’ ability to cause serious disease.

The group was the first to demonstrate the distribution and composition of influenza A virus receptors in the lungs of pigs. The group also participates in European and national projects working with other important viral infections such as PRRSV, Hepatitis E and virus in mink and wildlife. The projects also revolve around calf welfare, diarrhea in pigs, and innovation in the use of antibodies derived from whey and porcine plasma for the prevention of diarrhea in calves and weaners.

The research is conducted in both cell cultures and in animal models. They are establishing a reverse genetics system for manipulation of influenza virus, and the group uses both conventional sequencing and Next Generation Sequencing for detailed analyses of the evolution of virus.

Diagnostics and contingency

Research on influenza viruses is essential for the maintenance of a far-sighted contingency plan and a diagnostics portfolio that is up to date. At the same time the results contribute to important new knowledge that can be used directly in the assessment of the zoonotic risk of future new influenza viruses.

The work on common (endemic) virus infections is carried out in close cooperation with The Danish Agriculture & Food Council, and it contributes to Denmark's continued competitiveness in the production of livestock. The research also contributes to improved animal welfare, higher productivity, and higher food safety.


Professor

Lars Erik Larsen
Professor
DTU Vet
+45 35 88 62 74