Chemical research on the immune system

Chemistry

We use organic chemistry in the development of new diagnostic methods and biologically active agents for use in e.g. vaccines.

Regarding diagnostics, we work with new generic methods for conjugation of bacterial fragments (antigens), which are used in the development of multiplex assay platforms for measuring bacterial infections in animals and humans. It is our vision to provide methods which are more sensitive, faster, less expensive, and have a broader range of applications than existing methods.

We work with the design, preparation, and use of dendrimers. Dendrimers are nanoparticles based on tree-shaped molecules with a large number of reactive surface groups. These particles can bind strongly to different target molecules (e.g. proteins) in a sample from a patient or animal, and to receptors on the cell surfaces, or inside cells. These properties make dendrimers useful tools for the development of new biomedical agents as well as new diagnostic methods.

Effective vaccination

We deal in particular with dendrimers as immunostimulatory or immunosuppressive drugs. Immune stimulants can be used as adjuvants to enhance the effect of vaccines. Immune suppressant drugs could be interesting candidates in relation to the medical treatment of autoimmune diseases such as rheumatoid arthritis.

In this context, specific receptors on and in the cells of the innate immune system are interesting targets, given that binding to these receptors controls the formation of immunological memory, which is essential for a vaccine to have the desired effect.

Vaccination is the most important tool to fight the spread of diseases. Development of new technology platforms in diagnosis is important in the monitoring of disease and disease outbreaks. In agriculture, diagnostics is an important tool in the control of animal health and foodstuff.

Associate Professor

Ulrik Boas
Associate Professor
DTU Vet
+45 35 88 62 15