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Titel: Local osteogenic expression of cyclooxygenase-2 and systemic response in porcine models of osteomyelitis
Type: Journal articleJournal article
Person(er):
Forfatter:  Johansen, Louise K.
Faculty of Life Sciences, Copenhagen University

Forfatter:  Iburg, Tine M.
Faculty of Life Sciences, Copenhagen University

Forfatter:  Nielsen, Ole L.
Faculty of Life Sciences, Copenhagen University

Forfatter:  Leifsson, Páll S.
Faculty of Life Sciences, Copenhagen University

Forfatter:  Dahl-Petersen, Kirstin
Faculty of Life Sciences, Copenhagen University

Forfatter:  Koch, Janne
Faculty of Life Sciences, Copenhagen University

Forfatter:  Frees, Dorte
Faculty of Life Sciences, Copenhagen University

Forfatter:  Aalbæk, Bent
Faculty of Life Sciences, Copenhagen University

Forfatter:  Heegaard, Peter M. H. (Cwisno: 39404)
Innate Immunology Group, National Veterinary Institute, Technical University of Denmark, Copenhagen, Denmark
Email:

Forfatter:  Jensen, Henrik E.
Faculty of Life Sciences, Copenhagen University
Uddrag: It is suggested that cyclooxygenase 2 (COX-2) derived prostaglandins contributes to the progressive bone loss seen in osteomyelitis lesions. In the present study we examined the expression of COX-2 in bones from 23 pigs with experimental osteomyelitis. Osteomyelitis was induced with Staphylococcus aureus and groups of animals were euthanized following 6h, 12h, 24h, 2 days, 5 days, 11 days and 15 days, respectively. Expression of COX-2 was evaluated immunohistochemically and combined with characterization of morphological changes in bone tissue. Furthermore, the serum concentrations of alkaline phosphatase and haptoglobin were measured. Extensive COX-2 expression by osteoblasts was present 2 days after inoculation together with many activated osteoclasts. Simultaneously, the serum concentration of alkaline phosphatase decreased whereas the haptoglobin concentration increased. This is the first in vivo study showing an early wave of COX-2 mediated bone resorption during osteomyelitis. Therefore, treatment aiming to reduce the break down of bone tissue directed by the COX-2 pathway might be suggested early in the course of the disease.
Publiceret: in journal: Prostaglandins & Other Lipid Mediators (ISSN: 1098-8823) (DOI: http://dx.doi.org/10.1016/j.prostaglandins.2012.01.002), vol: 97, issue: 3-4, pages: 103-108, 2012
DOI:
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