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Titel: Investigations into shaking mink syndrome: an encephalomyelitis of unknown cause in farmed mink (Mustela vison) kits in Scandinavia
Type: Journal articleJournal article
Person(er):
Forfatter:  Gavier-Widen, Dolores
Technical University of Denmark

Forfatter:  Brojer, Caroline
Technical University of Denmark

Forfatter:  Dietz, Hans Henrik
Technical University of Denmark

Forfatter:  Englund, Lena
Technical University of Denmark

Forfatter:  Hammer, Anne Sofie (Cwisno: 39025)
Technical University of Denmark

Forfatter:  Hedlund, Kjell-Olof
Technical University of Denmark

Forfatter:  af Segerstad, Carl Hard
Technical University of Denmark

Forfatter:  Nilsson, Kristina
Technical University of Denmark

Forfatter:  Nowotny, Norbert
Technical University of Denmark

Forfatter:  Puurula, Vuokko
Technical University of Denmark

Forfatter:  Thoren, Peter
Technical University of Denmark

Forfatter:  Uhlhorn, Henrik
Technical University of Denmark

Forfatter:  Weissenbock, Herbert
Technical University of Denmark

Forfatter:  Agren, Erik
Technical University of Denmark

Forfatter:  Klingeborn, Berndt
Technical University of Denmark
Uddrag: An apparently novel neurological disease clinically characterized by shaking, tremors, seizures, staggering gait, and ataxia was first observed in farmed mink kits in Denmark in 2000 and subsequently in Sweden, Denmark, and Finland in 2001, and again in Denmark in 2002. Lymphoplasmacytic encephalomyelitis was found in the affected kits. The lesions were most severe in the brainstem and cerebellum and consisted of neuronal degeneration and necrosis, neuronophagia, focal and diffuse gliosis, perivascular cuffs formed by lymphocytes, plasma cells and macrophages, and segmental loss of Purkinje cells. Testing was conducted to determine the cause of the disease, including general virological investigations (virus culture, negative-staining electron microscopy, immunoelectron microscopy, polymerase chain reaction for herpesviruses, adenoviruses, pestiviruses, and coronaviruses), tests for specific viral diseases (canine distemper, Borna disease, Louping ill, West Nile virus infection, tick-borne encephalitis, Aleutian disease), tests for protozoa (Toxoplasma gondii, Neospora caninum, Encephalitozoon cuniculi), bacteria (general culture, listeria, Clamydophila psittaci), and intracerebral inoculation of neonatal mice. The results of all these investigations were negative. One group of 3 mink kits inoculated intracerebrally with brain homogenate of affected mink developed clinical signs and histological lesions similar to those observed in naturally infected mink. Based on the histopathological features, it is postulated that the disease is caused by a yet unidentified virus.
Publiceret: in journal: Journal of Veterinary Diagnostic Investigation (ISSN: 1040-6387), vol: 16, issue: 4, pages: 305-312, 2004
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