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Titel: The Incidence of Necrotizing Enterocolitis Is Increased Following Probiotic Administration to Preterm Pigs
Type: Journal articleJournal article
Person(er):
Forfatter:  Cilieborg, Malene Skovsted (Cwisno: 45428)
Technical University of Denmark
Email:

Forfatter:  Thymann, Thomas
University of Copenhagen, Faculty of Life Sciences

Forfatter:  Siggers, Richard
University of Copenhagen, Faculty of Life Sciences

Forfatter:  Boye, Mette (Cwisno: 7574)
Technical University of Denmark
Email:

Forfatter:  Bering, Stine B.
University of Copenhagen, Faculty of Life Sciences

Forfatter:  Jensen, Bent B.
University of Aarhus, Faculty of Agricultural Sciences

Forfatter:  Sangild, Per T.
University of Copenhagen, Faculty of Life Sciences
Uddrag: Preterm birth and necrotizing enterocolitis (NEC) is associated with inappropriate gut colonization and immunity, which may be improved by probiotic bacteria. Using a preterm pig model of NEC, we investigated the effects of probiotics on intestinal structure, function, microbiology, and immunology in the immediate postnatal period. Just after birth, caesarean-delivered preterm pigs were inoculated with Lactobacillus paracasei, Bifidobacteria animalis, and Streptococcus thermophilus (total 2.4 x 1010/d) either as live (ProLive, n = 14) or gamma-irradiated dead bacteria (ProDead, n = 12) and compared with controls (n = 14). All pigs received parenteral nutrition for 2 d followed by enteral formula feeding until tissue collection on d 5. Compared with control pigs, intestinal weight was lower and NEC incidence was higher in both groups given probiotics (64–67 vs. 14%; P
Publiceret: in journal: Journal of Nutrition (ISSN: 0022-3166) (DOI: http://dx.doi.org/10.3945/​jn.110.128561), vol: 141, issue: 2, pages: 223-230, 2011
DOI:
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