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| Title:
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Dendrimers for Vaccine and Immunostimulatory Uses |
| Type:
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Journal articleJournal article |
| Participant(s):
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Technical University of Denmark
Email:
Technical University of Denmark
Email:
Technical University of Denmark
Email:
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| Abstract:
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Dendrimers are well-defined (monodisperse) synthetic globular polymers with a range of interesting chemical
and biological properties. Chemical properties include the presence of multiple accessible surface functional groups
that can be used for coupling biologically relevant molecules and methods that allow for precise heterofunctionalization
of surface groups. Biologically, dendrimers are highly biocompatible and have predictable biodistribution
and cell membrane interacting characteristics determined by their size and surface charge. Dendrimers have optimal
characteristics to fill the need for efficient immunostimulating compounds (adjuvants) that can increase the efficiency
of vaccines, as dendrimers can provide molecularly defined multivalent scaffolds to produce highly defined
conjugates with small molecule immunostimulators and/or antigens. The review gives an overview on the use of
dendrimers as molecularly defined carriers/presenters of small antigens, including constructs that have built-in
immunostimulatory (adjuvant) properties, and as stand-alone adjuvants that can be mixed with antigens to provide
efficient vaccine formulations. These approaches allow the preparation of molecularly defined vaccines with highly
predictable and specific properties and enable knowledge-based vaccine design substituting the traditional
empirically based approaches for vaccine development and production. |
| Published:
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in journal: Bioconjugate Chemistry (ISSN: 1043-1802) (DOI: http://dx.doi.org/10.1021/bc900290d), vol: 21, issue: 3, pages: 405-418, 2010 |
| DOI:
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