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Title: Short-term study of the uptake of PrPSc by the Peyer’s patches in hamsters after oral exposure to scrapie
Type: Journal articleJournal article
Participant(s):
Forfatter:  Bergström, Ann-Louise
Technical University of Denmark

Author:  Jensen, Tim Kåre (Cwisno: 39468)
Technical University of Denmark
Email:

Author:  Heegaard, Peter M. H. (Cwisno: 39404)
Technical University of Denmark
Email:

Author:  Hvass, Henriette Cordes (Cwisno: 44837)
Technical University of Denmark
Email:

Forfatter:  Hansen, V. B.
Technical University of Denmark

Forfatter:  Laursen, H.
Technical University of Denmark

Author:  Lind, Peter (Cwisno: 39403)
Technical University of Denmark
Email:

Abstract: The disease-associated prion protein (PrPSc) has been detected in the ileal Peyer's patches of lambs as early as one week after oral exposure to scrapie. In hamsters, the earliest reported time of PrPSc detection in the Peyer's patches after oral exposure to scrapie is 69 days post-infection. To evaluate the acute uptake of inoculum and to investigate whether the Peyer's patches constitute the primary site of entry for scrapie after oral exposure, hamsters were each exposed orally to 1 ml of a 10% brain homogenate from hamsters in the terminal stage of infection with the 263 K strain of the scrapie agent. PrPSc was demonstrated in the Peyer's patches only a few days after exposure, i.e., much earlier than previously reported. This study Supports the view that the Peyer's patches constitute at least one of the primary entry sites of PrPSc after oral exposure to scrapie.
Published: in journal: Journal of Comparative Pathology (ISSN: 0021-9975) (DOI: http://dx.doi.org/10.1016/j.jcpa.2005.08.002), vol: 134, issue: 2-3, pages: 126-133, 2006
DOI:
See the publication in DTU Orbit See the publication in DTU Orbit

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