Title: Comparative protection of two different commercial vaccines against Yersinia ruckeri serotype O1 and biotype 2 in rainbow trout (Oncorhynchus mykiss)
Type: Journal articleJournal article
Participant(s):
Forfatter:  Deshmukh, S.
University of Copenhagen, Faculty of Life Sciences

Forfatter:  Raida, M. K.
University of Copenhagen, Faculty of Life Sciences

Author:  Dalsgaard, Inger (Cwisno: 39616)
Technical University of Denmark
Email:

Forfatter:  Chettri, J. K.
University of Copenhagen, Faculty of Life Sciences

Forfatter:  Kania, P. W.
University of Copenhagen, Faculty of Life Sciences

Forfatter:  Buchmann, K.
University of Copenhagen, Faculty of Life Sciences
Abstract: Differentially extended specific protection by two commercial vaccines against Yersinia ruckeri serotype O1 biotype 2 was studied following 30s immersion exposure. Rainbow trout were challenged intra-peritoneally (i.p.) with Y. ruckeri serotype O1, biotype 2 (≈106 to 107CFU/fish) at 4, 6 and 8 months after vaccination with vaccines containing either biotype 1 (AquaVac® ERM) or both biotypes 1 and 2 (AquaVac® RELERA™). The specific pattern of vaccine-mediated protection was evaluated by relative percentage survival (RPS) analysis at 4 and 6 months post-vaccination and by obtaining gross pathological observations at 4 and 8 months respectively. We determined specific significant and superior protection in terms of increased survivability in AquaVac® RELERA™ vaccinated fish and observed correspondingly fewer pathological changes. The challenge trials indicated a longer protection for at least 6 months without any booster vaccination. A specific and adaptive response induced by AquaVac® RELERA™ vaccine against Y. ruckeri biotype 2 was clearly indicated. In addition, some degree of cross protection rendered by AquaVac® ERM containing biotype 1 during infection with Y. ruckeri biotype 2 was also noted.
Published: in journal: Veterinary Immunology and Immunopathology (ISSN: 0165-2427) (DOI: http://dx.doi.org/10.1016/j.vetimm.2011.12.014), vol: 145, issue: 1-2, pages: 379-385, 2012
DOI:
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